Fats Domino has been played over 10 times on NTS, first on 4 March 2013. Fats Domino's music has been featured on 16 episodes.

Antoine Caliste Domino Jr. (February 26, 1928 – October 24, 2017), known as Fats Domino, was an American singer-songwriter and pianist. He was one of the early figures in the development of rock and roll and sold more than 65 million records during his career. Born in New Orleans, Louisiana, to a French Creole family, Domino signed with Imperial Records in 1949. His first single, "The Fat Man", has been cited by some historians as one of the earliest rock and roll records and among the first to sell more than one million copies. Domino continued to collaborate with the song’s co-writer Dave Bartholomew and contributed his piano playing to Lloyd Price’s 1952 recording "Lawdy Miss Clawdy". He achieved a series of mainstream hits beginning with "Ain't That a Shame" in 1955. Between 1955 and 1960 he had eleven singles reach the Top 10 of the US pop chart. By 1955, five of his records had sold more than one million copies and were certified gold.

Although known for a reserved and modest stage presence, Domino was widely regarded as an influential performer in early rock and roll. Elvis Presley cited Domino as an influence and referred to him as "the real king of rock 'n' roll" during a meeting in 1959. The Beatles also acknowledged his influence on their music.

Four of Domino’s recordings, "Blueberry Hill", "Ain't That a Shame", "Walking to New Orleans", and "The Fat Man", were later inducted into the Grammy Hall of Fame. In 1986 he was included in the first group of artists inducted into the Rock and Roll Hall of Fame. According to the Associated Press, Domino sold more than 110 million records worldwide during his career.

Studio albums Rock and Rollin' with Fats Domino (1956) Fats Domino Rock and Rollin' (1956) This Is Fats Domino! (1956) Here Stands Fats Domino (1957) This Is Fats (1957) The Fabulous Mr. D (1958) Alive and Kickin' (2006)