Róisín Murphy hosted a guest show on 4 May 2018. Róisín Murphy has been played over 70 times on NTS, first on 17 November 2014. Róisín Murphy's music has been featured on 70 episodes.

Róisín Murphy (pronounced roe-sheen) (born 5 July 1973 in Arklow, County Wicklow, Ireland,) gained fame with Mark Brydon as the lead vocalist for UK electronic duo Moloko, formed in 1995. Murphy recorded her first official solo material in 2004 with producer Matthew Herbert, who had previously done remixes for Moloko.

She released her debut album, Ruby Blue, in June 2005 in the UK on Echo Records. "Ruby Blue" produced two singles "If We're In Love" and "Sow Into You". She released her second album Overpowered on 15 October 2007.

On 10 January 2008, Overpowered received a nomination for the Choice Music Prize in the Republic of Ireland; the award is given each year to an Irish artist who has proved to produce a critically acclaimed album. Also Overpowered ended at #30 on Metacritic Best of 2007 albums with a score of 82.

Her version of "Slave to Love" by Bryan Ferry is featured in the 2008 Gucci commercial starring actor James Franco. The single "Let Me Know" was produced by Groove Armada. Overpowered produced four singles: "Overpowered," "Let Me Know," "You Know Me Better" and "Movie Star."

In addition to her work with Moloko, Murphy has contributed her vocals to the works of other artists including Handsome Boy Modeling School and Boris Dlugosch, for whom she sang on the track, Never Enough, which became a huge club hit.

On 15 December 2009, Róisín gave birth to her first child; a baby girl she named Clodagh.

‘Róisín Machine’ is the next chapter of that ever unfolding, always compelling tale – a seamlessly edited, 10 years in the making collection of tracks produced in collaboration with her Sheffield pal DJ Parrot, at once her most unabashedly dance-floor ready yet deeply autobiographical work to date.

In August 2023, Murphy sparked controversy when a Twitter user shared a screenshot from Facebook showing Murphy commenting on a post about Irish anti-transgender activist Graham Linehan, in which she criticised the use of puberty blockers for transgender youth. Her statements were met with backlash on social media, including responses from LGBT+ allies and activists accusing her of transphobia and misinformation. Commentators noted the disappointment of fans, particularly due to her perceived role as a gay icon. In the weeks following the comments, Murphy's material was removed from a scheduled BBC Radio 6 Music line-up, which had been due to broadcast five hours of her songs, interviews, and concert highlights. The BBC later stated that the schedule change was not a reaction to Murphy's comments.

Murphy later issued an apology on social media, stating she was "deeply sorry" for any hurt caused by her words. However, she did not take back her comments on puberty blockers, only writing her "concern was out of love for all of us".

In October 2025, Murphy posted to X/Twitter a graph of 18- to 22-year-olds identifying as transgender/non-binary along with the caption "It was never real.", drawing criticism over her apparent denial of the existence of transgender people. Organizers of music festivals then cancelled her upcoming appearances.