Roscoe Mitchell Sextet has been played on NTS in shows including Mutualism, featured first on 6 June 2020. Songs played include The Little Suite and Sound .

Roscoe Mitchell (b. August 3, 1940 in Chicago, Illinois) is an African American composer, jazz instrumentalist and educator, mostly known for being "a technically superb—if idiosyncratic—saxophonist." He has been called "one of the key figures" in avant-garde jazz who has been "at the forefront of modern music" for the past thirty years. He continues "to be a major figure." He has even been called a "super musician" and the New York Times has mentioned that he "qualifies as an iconoclast."

In 1965, Mitchell was one of the first members of the non-profit organization Association for the Advancement of Creative Musicians (AACM) along with Jodie Christian (piano), Steve McCall (drums), and Phil Cohran (composer). The following year Mitchell, Lester Bowie (trumpet), Kalaparusha Maurice McIntyre (tenor saxophone), Favors, Lester Lashley (trombone), and Alvin Fielder (drums), recorded their first studio album, Sound. The album was "a departure from the more extroverted work of the New York-based free jazz players" due in part to the band recording with "unorthodox devices" such as toys and bicycle horns.

From 1967 Mitchell, Bowie, Favors and, on occasion, Jarman performed as the Roscoe Mitchell Art Ensemble, then the Art Ensemble, and finally in 1969 were billed as the Art Ensemble of Chicago. The group included Phillip Wilson on drums for short span before he joined Paul Butterfield's band. The group lived and performed in Europe from 1969 to 1971, though they arrived without any percussionist after Wilson left. To fill the void, Mitchell commented that they "evolved into doing percussion ourselves."[6] The band did eventually get a percussionist, Don Moye, who Mitchell had played with before and was living in Europe at that time. For performances, the band often wore brilliant African costumes and painted their faces. The Art Ensemble of Chicago have been described as as becoming "possibly the most highly acclaimed jazz band" in the 1970s and 1980s.