Isaac Hayes has been played over 140 times on NTS, first on 3 November 2012. Isaac Hayes's music has been featured on 138 episodes.

Isaac Lee Hayes (born Aug 20, 1942, in Covington, Tennessee - died Aug 10, 2008, in Memphis, Tennessee) was an influential soul singer, songwriter, musician, producer, arranger, and actor. One of the key creative forces behind Memphis' Stax Records, Hayes began his recording career in 1962, soon playing saxophone for The Bar-Kays. Hayes and writing partner David Porter would pen numerous hits for Stax artists such as Sam & Dave ("Hold On! I'm Comin'", "Soul Man") and Carla Thomas ("B-A-B-Y") during the mid-1960s.

In the late 1960s and early 1970s, Hayes became famous as a recording artist in his own right, scoring with critically and commercially successful albums such as Hot Buttered Soul and Black Moses. Hayes is best known today for composing the score to the 1971 blaxploitation film Shaft. That film's "Theme from Shaft" was one of the best-selling singles in Stax Records history, and Hayes became the first African-American to win an Oscar for a non-acting category when "Theme from Shaft" won the 1972 Academy Award for Best Song.

Isaac Hayes may be known to today's youngest generation as the voice of the character "Chef", the ladies' man/school cook, on the animated sitcom South Park from 1997 until his resignation from the show in March 2006. While Hayes' departure was tagged to a controversial South Park episode on Scientology that had supposedly offended him, Hayes rarely declared anything about the departure in first person.